Cleaved-Factor XII HC (R372) 多克隆抗體-Cleaved-Factor XII HC (R372) Polyclonal Antibody代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: F12 encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in F12 do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.
蛋白別名為：F12; Coagulation factor XII; Hageman factor; HAF;基因ID為：2161；蛋白質ID:P00748

應用類型: WB，ELISA
補充：最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, ELISA: 1:20000. Not yet tested in other applications.

保存建議: 廠家推薦藍冰運輸.在發貨后能在-20℃保存1年.為最大限度的避免損失，請在打開管蓋之前融化抗體并離心.我們建議使用前分裝以避免反復凍融.
本產品為液體形式,溶解于PBS緩沖液中，含50%甘油，0.5%BSA和0.02%NaN3.

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