ERBIN is a member of the leucine-rich repeat and PDZ domain (LAP) family.Erbb2 interacting protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for ERBIN.蛋白別名為:ERBB2IP; ERBIN; KIAA1225; LAP2; Protein LAP2; Densin-180-like protein; Erbb2-interacting protein; Erbin;基因ID為:55914;蛋白質ID:Q96RT1
應用類型
WB,ELISA補充:最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, ELISA: 1:10000. Not yet tested in other applications.
免疫原
合成多肽:human Erbin around the phosphorylation site of Y1104.