The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. DAB1 is similar to disabled-1, and the protein encoded by DAB1 is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of DAB1 have been reported, but their full length nature has not been determined.蛋白別名為：DAB1; Disabled homolog 1;基因ID為：1600；蛋白質ID:O75553
應用類型
WB，IF，ELISA補充：最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, IF: 1:200-1:1000, ELISA: 1:20000. Not yet tested in other applications.
免疫原
合成多肽：human Dab1 around the non-phosphorylation site of Y232.
