Dok-1, Dok-2 and Dok-3 are members of a class of "docking" proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl.Dok-3 is an adapter involved in the recruitment of inhibitory molecules and is highly expressed in B cells and macrophages.Immunoreceptor-mediated cellular activation induces tyrosine phosphorylation of Dok-3.Upon phosphorylation, Dok-3 binds to 5' inositol phosphatase SHIP and the protein tyrosine kinase Csk.Dok-3 may play a significant role in the negative regulation of immunoreceptor signaling in hemopoietic cells.蛋白別名為：DOK3; Docking protein 3; Downstream of tyrosine kinase 3;基因ID為：79930；蛋白質ID:Q7L591
應用類型
WB，IHC-p，IF，ELISA補充：最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, IF: 1:200-1:1000, ELISA: 1:20000. Not yet tested in other applications.
免疫原
合成多肽：the Internal region of human Dok-3. at AA rangle: 70-150
