MyD88 encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. Myeloid differentiation primary response protein MyD88 functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. 蛋白別名為：MYD88; Myeloid differentiation primary response protein MyD88;基因ID為：4615；蛋白質ID:Q99836
應用類型
WB，IHC-p，ELISA補充：最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300. Immunocytochemistry: 1:200-1:1000, ELISA: 1:20000. Not yet tested in other applications.
