NEDD8 is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p53 pathway (Pathway Interaction Database). Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is UBA52.蛋白別名為：NEDD8; NEDD8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; NEDD-8; Ubiquitin-like protein Nedd8;基因ID為：4738；蛋白質ID:Q15843
應用類型
WB，IHC-p，ELISA補充：最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, ELISA: 1:5000. Not yet tested in other applications.
免疫原
合成多肽：the N-terminal region of human Neddylin. at AA rangle: 10-90
