Tumor protein p53 inducible protein 3 encoded by TP53I3 is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. TP53I3 is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate TP53I3 by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for TP53I3.蛋白別名為：TP53I3; PIG3; Quinone oxidoreductase PIG3; Tumor protein p53-inducible protein 3; p53-induced gene 3 protein;基因ID為：9540；蛋白質ID:Q53FA7
應用類型
WB，IHC-p，ELISA補充：最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, ELISA: 1:20000. Not yet tested in other applications.
免疫原
合成多肽：the C-terminal region of human PIG3. at AA rangle: 210-290
