BTC encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of betacellulin bind to multiple different EGF receptors. Betacellulin romotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in BTC may be associated with type 2 diabetes in human patients.蛋白別名為:BTC; Probetacellulin;基因ID為:685;蛋白質ID:P35070
應用類型
WB,ELISA補充:最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, ELISA: 1:40000. Not yet tested in other applications.
免疫原
合成多肽:the Internal region of human Probetacellulin. at AA rangle: 60-140