Signal transducing adapter molecule 2 encoded by STAM2 is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.蛋白別名為:STAM2; HBP; Signal transducing adapter molecule 2; STAM-2; Hrs-binding protein;基因ID為:10254;蛋白質ID:O75886
應用類型
WB,IHC-p,IF,ELISA補充:最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, IF: 1:200-1:1000, ELISA: 1:40000. Not yet tested in other applications.
免疫原
合成多肽:human STAM2 around the non-phosphorylation site of Y192.