MYO6 encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The unconventional myosin-VI consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. 蛋白別名為：MYO6; KIAA0389; Unconventional myosin-VI; Unconventional myosin-6;基因ID為：4646；蛋白質ID:Q9UM54
應用類型
WB，IHC-p，ELISA補充：最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, IHC-p: 1:100-300 ELISA: 1:5000. Not yet tested in other applications.
免疫原
合成多肽：the N-terminal region of human Myosin VI. at AA rangle: 40-120
