HNF1B encodes a member of the homeodomain-containing superfamily of transcription factors. Hepatocyte nuclear factor 1-beta binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.蛋白別名為:HNF1B; TCF2; Hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF-1B; Homeoprotein LFB3; Transcription factor 2; TCF-2; Variant hepatic nuclear factor 1; vHNF1;基因ID為:6928/6928;蛋白質ID:P35680
應用類型
WB,ELISA補充:最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, ELISA: 1:10000. Not yet tested in other applications.