Calbindin encoded by CALB1 is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease.蛋白別名為:CALB1; CAB27; Calbindin; Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type;基因ID為:793;蛋白質ID:P05937
應用類型
WB,IHC-p,ELISA補充:最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, IHC-p: 1:100-300 ELISA: 1:20000. Not yet tested in other applications.
免疫原
合成多肽:the C-terminal region of human Calbindin D28K.