GRM1 encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. 蛋白別名為：GRM1; GPRC1A; MGLUR1; Metabotropic glutamate receptor 1; mGluR1;基因ID為：2911；蛋白質ID:Q13255
應用類型
IHC-p，ELISA補充：最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: IHC-p: 1:100-1:300, ELISA: 1:5000. Not yet tested in other applications.
免疫原
合成多肽：the Internal region of human mGluR1. at AA rangle: 220-300
