Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC7(histone deacetylase 7) has sequence homology to members of the histone deacetylase family. HDAC7 is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.蛋白別名為:HDAC7; HDAC7A; Histone deacetylase 7; HD7; Histone deacetylase 7A; HD7a;基因ID為:51564;蛋白質ID:Q8WUI4
應用類型
WB,ELISA補充:最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, ELISA: 1:40000. Not yet tested in other applications.
免疫原
合成多肽:human HDAC7 around the phosphorylation site of S155.