Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. SCN2A encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in SCN2A have been linked to several seizure disorders. Several alternatively spliced transcript variants of SCN2A have been described, but the full-length nature of some of these variants has not been determined.蛋白別名為：SCN2A; NAC2; SCN2A1; SCN2A2; Sodium channel protein type 2 subunit alpha; HBSC II; Sodium channel protein brain II subunit alpha; Sodium channel protein type II subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.2;基因ID為：6326；蛋白質ID:Q99250
應用類型
IHC-p，ELISA補充：最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: IHC-p: 1:100-1:300, ELISA: 1:40000. Not yet tested in other applications.
免疫原
合成多肽：the Internal region of human Na+ CP type IIα.
