The protein encoded by this intronless gene THBD(thrombomodulin) is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in THBD are a cause of thromboembolic disease, also known as inherited thrombophilia.蛋白別名為:THBD; THRM; Thrombomodulin; TM; Fetomodulin; CD antigen CD141;基因ID為:7056;蛋白質ID:P07204
應用類型
WB,ELISA補充:最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, ELISA: 1:5000. Not yet tested in other applications.
免疫原
合成多肽:the C-terminal region of human CD141. at AA rangle: 500-580