TIE1（tyrosine kinase with immunoglobulin like and EGF like domains 1） encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for TIE1.蛋白別名為：TIE1; TIE; Tyrosine-protein kinase receptor Tie-1;基因ID為：7075；蛋白質ID:P35590
應用類型
WB，ELISA補充：最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, ELISA: 1:10000. Not yet tested in other applications.
免疫原
合成多肽：the Internal region of human Tie-1. at AA rangle: 820-900
