HIRA（histone cell cycle regulator） encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of HIRA in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.蛋白別名為：HIRA; DGCR1; HIR; TUPLE1; Protein HIRA; TUP1-like enhancer of split protein 1;基因ID為：7290；蛋白質ID:P54198
應用類型
IHC-p，ELISA補充：最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: IHC-p: 1:100-1:300, ELISA: 1:10000. Not yet tested in other applications.
免疫原
合成多肽：human HIRA around the non-phosphorylation site of T555.
