The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. CAD（carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase） encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.蛋白別名為：CAD; CAD protein;基因ID為：790；蛋白質ID:P27708
應用類型
IHC-p，ELISA補充：最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: IHC-p: 1:100-1:300, ELISA: 1:5000. Not yet tested in other applications.
免疫原
合成多肽：human CAD around the phosphorylation site of T456.
