BCL2L12 (BCL2 like 12)encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of BCL2L12 has been detected in a number of different cancers. There is a pseudogene for BCL2L12 on chromosome 3. Alternative splicing results in multiple transcript variants.蛋白別名為:BCL2L12; BPR; Bcl-2-like protein 12; Bcl2-L-12; Bcl-2-related proline-rich protein;基因ID為:83596;蛋白質ID:Q9HB09
應用類型
WB,ELISA補充:最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, ELISA: 1:5000. Not yet tested in other applications.
免疫原
合成多肽:the Internal region of human BCL2L12. at AA rangle: 60-140