ULK1 多克隆抗體-ULK1 Polyclonal Antibody代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: Two related serine/threonine kinases, UNC-51-like kinase 1 and 2 (ULK1, ULK2), were discovered as mammalian homologs of the C. elegans gene UNC-51 in which mutants exhibited abnormal axonal extension and growth. Both proteins are widely expressed and contain an amino-terminal kinase domain followed by a central proline/serine rich domain and a highly conserved carboxy-terminal domain. The roles of ULK1 and ULK2 in axon growth have been linked to studies showing that the kinases are localized to neuronal growth cones and are involved in endocytosis of critical growth factors, such as NGF . Yeast two-hybrid studies found ULK1/2 associated with modulators of the endocytic pathway, SynGAP and syntenin . Structural similarity of ULK1/2 has also been recognized with the yeast autophagy protein Atg1/Apg1 . Knockdown experiments using siRNA demonstrated that ULK1 is essential for autophagy , a catabolic process for the degradation of bulk cytoplasmic contents . It appears that Atg1/ULK1 can act as a convergence point for multiple signals that control autophagy , and can bind to several autophagy-related (Atg) proteins, regulating phosphorylation states and protein trafficking .
蛋白別名為：ULK1; KIAA0722; Serine/threonine-protein kinase ULK1; Autophagy-related protein 1 homolog; ATG1; hATG1; Unc-51-like kinase 1;基因ID為：8408；蛋白質ID:O75385

應用類型: IHC-p，ELISA
補充：最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: IHC-p: 1:100-1:300, ELISA: 1:40000. Not yet tested in other applications.

保存建議: 廠家推薦藍冰運輸.在發貨后能在-20℃保存1年.為最大限度的避免損失，請在打開管蓋之前融化抗體并離心.我們建議使用前分裝以避免反復凍融.
本產品為液體形式,溶解于PBS緩沖液中，含50%甘油，0.5%BSA和0.02%NaN3.

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