HNRNPDL(heterogeneous nuclear ribonucleoprotein D like) belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by HNRNPDL has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for HNRNPDL. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by HNRNPDL are similar to its family member HNRPD.蛋白別名為:HNRPDL; JKTBP; Heterogeneous nuclear ribonucleoprotein D-like; hnRNP D-like; hnRNP DL; AU-rich element RNA-binding factor; JKT41-binding protein; Protein laAUF1;基因ID為:9987;蛋白質ID:O14979
應用類型
IHC-p,ELISA補充:最優的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: IHC-p: 1:100-1:300, ELISA: 1:20000. Not yet tested in other applications.
免疫原
合成多肽:the Internal region of human hnRNP DL. at AA rangle: 210-290