IRF3（interferon regulatory factor 3） encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for IRF3.蛋白別名為：Interferon regulatory factor 3 (IRF-3);基因ID為：3661；蛋白質ID:Q14653
