SOCS3 encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of SOCS3 is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by SOCS3 can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of SOCS3 suggested the roles of SOCS3 in the negative regulation of fetal liver hematopoiesis, and placental development. SOCS3 (Suppressor Of Cytokine Signaling 3) is a Protein Coding gene. Diseases associated with SOCS3 include Overnutrition and Atopic Dermatitis. Among its related pathways are Type II interferon signaling (IFNG) and Adipocytokine signaling pathway.
