KPNA1 (Karyopherin Subunit Alpha 1) is a Protein Coding gene. Diseases associated with KPNA1 include Influenza and Ovarian Endodermal Sinus Tumor. Among its related pathways are HIV Life Cycle and Apoptosis induced DNA fragmentation. The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by KPNA1 belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase.
