Angiotensin II receptor type 1 or AT1 receptor is one of the receptors that binds the octapeptide hormone Angiotensin II (Ang II).Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects.Most of the physiological actions of Ang II are mediated by AT1 receptor a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.
應用類型
經驗證，該抗體可應用于IC、IFC、IH、LCI、WB等實驗應用，也可用于 IP等實驗。
免疫原
Angiotensin II 受體 Type-1 (胞外)抗體的免疫原肽段為NSSTEDGIKRIQDDC。此免疫原序列來源于4-18位氨基酸殘基，該序列來源于人類AT1 受體 (Accession編號為P30556)。胞外, N端
來源宿主
兔
反應性
反應性：人、 小鼠、 大鼠
保存建議
艾美捷為您提供的Angiotensin II 受體 Type-1 (胞外)抗體(50 ul)為室溫運輸，建議您收到產品后﹣20℃保存。
