Angiotensin II receptor type 2 or AT2 is one of the receptors that bind the octapeptide hormone Angiotensin II (Ang II).Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects.Most of the physiological actions of Ang II are mediated by AT1 a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. AT2 is also a GPCR, and is largely believed to have counter-regulatory roles to the ones exerted through the AT1 receptor. Hence, binding of Ang II to the AT2 receptor will result in growth arrest and apoptosis, vasodilatation and hypotension.
應用類型
經驗證，該抗體可應用于IC、IH、LCI等實驗。
免疫原
Angiotensin II 受體 Type-2 (胞外)抗體的免疫原肽段為DNLNATGTNESAFNC。此免疫原序列來源于21-35 位氨基酸殘基，該序列來源于大鼠AT2 受體 (Accession編號為P35351)。胞外, N端。
來源宿主
兔
反應性
反應性：小鼠、 大鼠
保存建議
艾美捷為您提供的Angiotensin II 受體 Type-2 (胞外)抗體(50 ul)為室溫運輸，建議您收到產品后﹣20℃保存。
