The angiotensin-(1-7) Mas receptor is the recently identified receptor of the biologically active heptapeptide angiotensin-(1-7).Angiotensin (Ang)-(1-7) is a metabolite of the well known peptide hormone Angiotensin (Ang) II, a key component of the renin-angiotensin system (RAS) that has a central role in cardiovascular homeostasis.n Considerably interest in Ang-(1-7) and its receptor aroused in the last few years since it became apparent that it can counterbalance most of Ang II effects. Thus Ang-(1-7) has vasodilator and hypotensive effects as well as antiarrhythmic and cardioprotective roles.The Ang-(1-7) Mas receptor belongs to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily and was originally described as a protooncogene.Signaling via the Ang-(1-7) Mas receptor is still poorly elucidated however, evidence indicates that the receptor is coupled to a Gq/11 protein that activates phospholipase C (PLC).The Ang-(1-7) Mas receptor is expressed in several organs including heart, kidney, blood vessels, testis and brain. Studies with Ang-(1-7) Mas receptor knockout mice have demonstrated the key role of this receptor in cardiovascular regulation as well as in the regulation of learning and memory.
應用類型
經驗證，該抗體可應用于IH、WB等實驗應用，也可用于 IC、IFC、IP等實驗。
免疫原
Angiotensin-(1-7) Mas 受體抗體的免疫原肽段為(C)KIRKNTWASHSSK。此免疫原序列來源于212-224 位氨基酸殘基，該序列來源于大鼠Angiotensin-(1-7) Mas 受體 (Accession編號為P12526)，第三胞內環。
來源宿主
兔
反應性
反應性：人、 小鼠、 大鼠
保存建議
艾美捷為您提供的Angiotensin-(1-7) Mas 受體抗體(50 ul)為室溫運輸，建議您收到產品后﹣20℃保存。
