- 中文名稱
Bombesin受體2（胞外）抗體（50 ul）
- 英文名字
- Anti-Bombesin Receptor 2 （extracellular)
- 供應商
- Alomone
- 產品貨號
- ALO-ABR-002-50
- 產品報價
- ￥已停產
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868。
- 產品新聞
- 背景資料
- Bombesin receptor 2 (BB2) is a member of a family of receptors that binds the 14 amino acid peptide, bombesin. Bombesin was first isolated from frog skin and it was later established that mammals express endogenous bombesin-like peptides such as gastrin-releasing peptide (GRP; a 27 amino acid homologue) and neuromedin B (NMB; a 10 amino acid homologue).BB2 is the preferred receptor for GRP and hence it is also referred to as GRP receptor or GRP-R.1 BB1 is the preferred receptor for NMB and therefore it is also known as NMB-R. A third member (called BB3) of the bombesin receptor family has been recognized but the endogenous mammalian ligand for this receptor remains to be identified.All three bombesin receptors are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. BB2 is coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), intracellular Ca2+ mobilization, and cell growth.GRP (through its binding to BB2) plays an essential role in the release of hormones in the intestinal tract, the regulation of smooth muscle contraction, and the secretion of pancreatic enzymes. In the brain, BB2 has been implicated in regulating feeding behavior, thermoregulation, and memory formation.Finally, BB2 is overexpressed in several human tumors including breast, prostate, and lung, where it acts as a growth factor receptor inducing tumor growth. BB2 is considered a potential target for the development of both diagnostics and anti-cancer therapies.
- 應用類型
- 經驗證，該抗體可應用于IC、IH、LCI、WB等實驗應用等實驗應用，也可用于IFC、IP等實驗。
- 免疫原
- Bombesin 受體 2 (胞外)抗體的免疫原肽段為(C)RSYHYSEVDTSMLH。此免疫原序列來源于287-300位氨基酸殘基，該序列來源于人類BB2 (Accession編號為P30550)，第3胞外環。
- 來源宿主
- 兔
- 反應性
- 反應性：人、 小鼠、 大鼠
- 保存建議
- 艾美捷為您提供的Bombesin 受體 2 (胞外)抗體(50 ul)為室溫運輸，建議您收到產品后﹣20℃保存。
- 其他
- Alomone成立于1989年,已經成為全世界科學家信賴的最全面的離子通道研究工具供應商。產品覆蓋離子通道、G蛋白耦聯受體和神經信號研究所需的一抗、小分子、蛋白質和多肽等。所有Alomone產品均進行了生物實驗驗證，以凍干粉形式提供，可確保產品生物活性和保質期。Alomone可提供多種包裝規格，靈活方便。作為Alomone Labs在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Alomone Labs產品以及客戶訂制化服務。
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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