膽汁酸受體抗體（50 ul）-Anti-Bile Acid Receptor代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: Bile acids are endogenous ligands for TGR5, a G-protein coupled receptor. Bile acids are important amphipathic biomolecules which can help absorption of dietary lipids and fat-soluble vitamins in the intestine. The TGR5 receptor is the first known G-protein coupled receptor specific for bile acids.The coding sequence of the TGR5 gene contains 993 base pairs, encoding a protein of 330 amino acids. The receptor comprises seven transmembrane helices, three extracellular loops contributing to ligand binding, and three intracellular loops involved in mediating the signal to downstream signaling molecules.TGR5 gene expression is widely distributed, including endocrine glands, adipocytes, muscles, immune organs, spinal cord, and the enteric nervous system.Animal studies suggest that TGR5 activation influences energy production and thereby may be involved in obesity and diabetes. TGR5 activation also influences intestinal motility. TGR5 is now recognized as a potential target for the treatment of metabolic disorders, such as type 2 diabetes1. In addition, the ability of TGR5 to lower the levels of proinflammatory cytokines in monocytes has opened new insights into the modulatory role of bile acids in pathology where inflammatory processes play a central role, including colitis and atheroma development.

免疫原: Bile Acid 受體抗體的免疫原肽段為(C)GDQRYTAPWRTAAQR。此免疫原序列來源于282-296 位氨基酸殘基，該序列來源于大鼠GPBAR1 (Accession編號為P41587)。胞內, C端。

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