All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptor. While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of CaV1.2 is ubiquitous and CaV1.3 channels are found in heart, brain and pancreas. Several peptidyl toxins are described that are specific L-type channels blockers, but so far no selective blocker for one of the CaV1 isoforms have been described.
應用類型
經驗證，該抗體可應用于IC、WB等實驗。
免疫原
human CaV1.2抗體的免疫原肽段為VNENTRMYIPEENHQ(C)。此免疫原序列來源于2-15位氨基酸殘基，該序列來源于人類Cav1。2 (exon 1B) (Accession編號為Q13936)。胞內, N端
