TRPM6（胞外）抗體（50 ul）-Anti-TRPM6 （extracellular)代理/參數/廠家-一抗-艾美捷科技有限公司

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中文名稱: TRPM6（胞外）抗體（50 ul）

英文名字: Anti-TRPM6 （extracellular)

供應商: Alomone

產品貨號: ALO-ACC-046-50

產品報價: ￥已停產

產品說明書: 點擊查看

購買方式: 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868。

產品新聞

背景資料: ransient receptor potential (TRP) channels are relatively non-selective ion channels enabling the exchange of cations down their electrochemical gradient. This exchange enables the intracellular rise in Na+ and Ca2+ concentration and ultimately in the cell membrane depolarization, important for action potential propagation and muscle contraction1. They are activated by an extremely broad range of stimuli namely, temperature, voltage, pH, endocrine factors as well as signaling molecules.The TRP channel family is composed of 28 members divided in 7 subgroups: TRPV, TRPC, TRPM, TRPA, TRPN, TRPP and TRPML. All members of the TRP family have 6 transmembrane (TM) domains, and a pore domain between the fifth (S5) and sixth (S6) transmembrane domains. In general, TRP channels enable the passage of either Na+ or Ca2+ ions with little or no preference. However, some channels do exhibit some selectivity. Also, TRP channels do not display the positive charges in the S4 voltage-sensing domain like most voltage sensitive channels, although they do display voltage dependency. In addition, TRP channels have in the C-terminal intracellular region to the S6 domain a TRP domain comprising 25 amino acids that is more or less conserved among most TRP channels. Within the TRP domain, there is a TRP box composed of six amino acids, and TRP box 2 – a proline rich domain. The TRP domain seems to be responsible for the binding of PIP2, a phospholipid important for the regulation of channel activity.The TRPM subfamily consists of 8 members divided in to three major groups: TRPM1/3, TRPM4/5, and TRPM6/7. TRPM2 and TRPM8 are not included in any of the groups since they are quite different even with respect to each other. TRPM2, TRPM6 and TRPM7 are distinctly different from the other TRP channels and other ion channels as all three have an active kinase domain in the C-terminal tail. TRPM6 kinase domain is able to phosphorylate TRPM7 thus increasing TRPM7 channel activity. However, TRPM7 cannot phosphorylate TRPM65; it can though autophosphorylate and phosphorylate other proteins. The significance of the kinase activity of these two channels has yet to be determined. Both channels are regulated by cytosolic Mg2+. Extracellular Mg2+ inhibits the channels. Both TRPM6 and TRPM7 are thus important regulators of Mg2+ homeostasis7. TRPM7 does so in a more or less ubiquitous manner whereas TRPM6 does so selectively in the kidney and intestines where it is selectively expressed. Indeed, mutations in TRPM6 results in hypomagnesemia with secondary hypocalcemia8-10. TRPM6 and TRPM7 are able to form homo- and heterodimers, where every channel-type formed demonstrates different properties related to cation affinity, and pH sensitivity.

應用類型: 經驗證，該抗體可應用于WB等實驗應用，也可用于IC、IFC、IP、LCI等實驗。

免疫原: TRPM6 (胞外)抗體的免疫原肽段為GSGKKRGKFVKVPS(C)。此免疫原序列來源于32-45 位氨基酸殘基，該序列來源于小鼠 TRPM5 (Accession編號為Q9JJH7)。胞內, N端

來源宿主: 兔

反應性: 反應性：小鼠、大鼠、也可反應于：人

保存建議: 艾美捷為您提供的TRPM6 (胞外)抗體(50 ul)為室溫運輸，建議您收到產品后﹣20℃保存。

其他: Alomone成立于1989年,已經成為全世界科學家信賴的最全面的離子通道研究工具供應商。產品覆蓋離子通道、G蛋白耦聯受體和神經信號研究所需的一抗、小分子、蛋白質和多肽等。所有Alomone產品均進行了生物實驗驗證，以凍干粉形式提供，可確保產品生物活性和保質期。Alomone可提供多種包裝規格，靈活方便。作為Alomone Labs在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Alomone Labs產品以及客戶訂制化服務。