- 中文名稱
STIM1（胞外）抗體（25 ul）
- 英文名字
- Anti-STIM1 （extracellular)
- 供應商
- Alomone
- 產品貨號
- ALO-ACC-063-25
- 產品報價
- ￥已停產
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868。
- 產品新聞
- 背景資料
- Cytosolic Ca2+ has long been known to act as a key second messenger in many intracellular pathways including synaptic transmission, muscle contraction, hormonal secretion, and cell growth and proliferation.The mechanism controlling the influx of intracellular Ca2+ either by calcium-release-activated Ca2+ channels (CRAC) or from intracellular stores has lately become of great interest.Recently, several key players of the store-operated complex have been identified.The Orai family consists of three members, Orai1-3, and the STIM family, which consists of two members, STIM1 and STIM2. Orai1 (also known as CRACM1) acts as the store-operated calcium channel (SOC) and STIM1 as the endoplasmic reticulum (ER) Ca2+ sensor. The majority of STIM1 appears to be localized intracellularly at the ER membrane while low expression of STIM1 has been detected on the cell surface of several cell types.STIM1 has an amino-terminal EF hand Ca2+ -binding domain facing the lumen of the ER. Upon Ca2+ store depletion, STIM1 molecules are redistributed in punctae underneath the plasma membrane and activate SOCs.Several possible interactions between STIM1 and Orai1 have been suggested. The most simple and cited is a dynamic interaction between the cytosolic C-terminus of STIM1 and the cytoplasmic domain of the Orai1 channel. STIM1 is assumed to regulate the activity of all known SOCs, including native SOCs. Consistent with their important role as calcium sensors within the ER, STIM1 proteins are ubiquitously expressed.
- 應用類型
- 經驗證，該抗體可應用于IC、IFC、IH、IP、LCI、WB等實驗。
- 免疫原
- STIM1 (胞外)抗體的免疫原肽段為CHSEDEKLSFEAVR。此免疫原序列來源于56-69位氨基酸殘基，該序列來源于人類STIM1 (Accession編號為Q13586)。 STIM1 expressed on the plasma membrane: 胞外, N端 STIM1 expressed on the ER: Luminal, N端
- 來源宿主
- 兔
- 反應性
- 反應性：人、 小鼠、 大鼠
- 保存建議
- 艾美捷為您提供的STIM1 (胞外)抗體(25 ul)為室溫運輸，建議您收到產品后﹣20℃保存。
- 其他
- Alomone成立于1989年,已經成為全世界科學家信賴的最全面的離子通道研究工具供應商。產品覆蓋離子通道、G蛋白耦聯受體和神經信號研究所需的一抗、小分子、蛋白質和多肽等。所有Alomone產品均進行了生物實驗驗證，以凍干粉形式提供，可確保產品生物活性和保質期。Alomone可提供多種包裝規格，靈活方便。作為Alomone Labs在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Alomone Labs產品以及客戶訂制化服務。
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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