IP3受體-2-ATTO-594抗體（50 ul）-Anti-IP3 Receptor-2-ATTO-594代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: Three subtypes of IP3Rs, derived from three distinct genes, have been identified in mammals. All three receptors have six transmembrane domains and a pore domain between TM5 and TM6. The N-terminus as well as the C-terminus are cytoplasmic. Each IP3R consists of an N-terminal ligand binding domain (LBD) and a C-terminal domain which is linked by a long regulatory domain. The C-terminus is constitutively active, suggesting that the regulatory domain is required to maintain the suppression of channel activity. n Type 2 IP3R (IP3R2) is expressed in various tissues and cell lines. IP3R2 mRNA is localized in the intralobular duct cells of the submandibular gland, the urinary tubule cells of the kidney, the epithelial cells of epididymal ducts and the follicular granulosa cells of the ovary5. IP3R2 is active during osteoclast differentiation, and its absence causes a partial defect in osteoclastic differentiation. ATTO dyes are characterized by strong absorption (high extinction coefficient), high fluorescence quantum yield, and high photo-stability. The ATTO-594 fluorescent label belongs to the class of Rhodamine dyes and can be used with fluorescent equipment typically optimized to detect Texas Red and Alexa-594.

免疫原: IP3 受體-2-ATTO-594抗體的免疫原肽段為(C)RLGFLGSNTPHENH。此免疫原序列來源于2683-2696 位氨基酸殘基，該序列來源于大鼠IP3R2 (Accession編號為P29995)。胞內, C端。

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