CLC-K channels require the presence of the auxiliary b subunit barttin, a 34 kD transmembrane protein, for transport to the plama membrane and regulation of channel permeation and gating.CLC-K channels are expressed primarily in the kidney from the thin ascending limb to the collecting duct of the nephron, and in the stria vascularis and dark cells of the vestibular organ of the inner ear.The channels are important for renal salt reabsorption and water balance by enabling chloride exit across the basolateral membranes. The importance of the CLC-K channel in renal function is demonstrated by the fact that loss-of-function mutations in CLC-Kb lead to Bartter syndrome type III, an autosomal recessive disorder characterized by severe salt wasting, low blood pressure, hypokalemia and hypercalciuria.
應用類型
經驗證，該抗體可應用于IH、WB等實驗應用，也可用于IC、IFC、IP等實驗。
免疫原
CLC-K抗體的免疫原肽段為(C)KKAISTLTNPPAPK。此免疫原序列來源于674-687 位氨基酸殘基，該序列來源于大鼠longer form CLC-K2L (Accession編號為# P51802)。胞內, C端。
