CLIC4抗體（50 ul）-Anti-CLIC4代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: Chloride intracellular channel (CLIC) is a family of proteins encoded by six different genes (CLIC1-6).nThe localization of the various CLIC channels remains elusive and controversial since they can be either found in a soluble form in the cytoplasm or as integral membrane proteins (in intracellular compartments such as the nuclear membrane or the endoplasmic reticulum for example, or associate to the plasma membrane) via their single transmembrane domain.nWhen membrane associated, CLIC channels indeed function as ion channels (enabling the passage of Cl- ions). Non-channel functions are also attributed to CLICs and include cell cycle regulation, cell differentiation, and apoptosis. These different roles depend whether CLICs are membrane bound or cytosolic1. For instance, CLIC4 is involved in keratinocyte differentiation in a TGFb-dependent manner, in such a way that TGFb stimulation induces the expression and nuclear localization of CLIC4 and its subsequent interaction with transcription factors4. CLIC4 is also required for growth arrest and apoptosis under stress.nCLIC4 distribution is rather ubiquitous but shows higher expression level in skin, kidney, brain and testes.

免疫原: CLIC4抗體的免疫原肽段為(C)NGLKEEDKEPLIE。此免疫原序列來源于8 - 20位氨基酸殘基，該序列來源于人類CLIC4 (Accession編號為Q9Y696)。胞內, N端

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