鈣敏感受體（胞外）抗體（50 ul）-Anti-Calcium Sensing Receptor （extracellular)代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: The Calcium-Sensing Receptor (CaSR) is a member of subfamily C of the G-protein-coupled receptor (GPCR) superfamily. As its primary role, the CaSR is a key player in calcium homeostasis and is expressed in tissues involved in calcium metabolism, such as parathyroid cells and kidney.nThe expression of CaSR was also described in other cell types and tissues, such as neurons, keratinocytes, and pancreas. However, the role of CaSR in these cells remains to be established.Following the identification of functional vitamin D response elements in the CaSR gene, it was suggested that vitamin D might regulate the expression of CaSR.nCaSR activation is followed by a rapid, transient increase in the cytosolic calcium concentration, resulting from mobilization of calcium from thapsigargin-sensitive intracellular stores, as well as an increased calcium influx through voltage-insensitive calcium channels located at the cell membrane.nCaSR regulates cellular processes such as proliferation, apoptosis, and differentiation under both normal and pathologic conditions.nRecent studies demonstrated the expression in human colon epithelium of CaSR, which regulates proliferation and differentiation. In colon carcinomas,lower levels of expression were found in compared to normal colon tissue.

免疫原: Calcium Sensing 受體 (胞外)抗體的免疫原肽段為(C)DDYG RPGIE KFREE。此免疫原序列來源于216-229位氨基酸殘基，該序列來源于人類CaSR (Accession編號為P41180)。 N端, 胞外。

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