CXCR4（胞外）-ATTO-488抗體（50 ul）-Anti-CXCR4 （extracellular)-ATTO-488代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: CXCR4 was originally identified as an orphan receptor, and soon gained much attention when it was discovered as a coreceptor for HIV-14. Besides from being involved in HIV-1 infection/progression, CXCR4 is found to be upregulated in many different cancers/tumors and has evolved to become a target for the development of antagonists5. CXCL12 (SDF-1α) is the sole ligand for CXCR4. Following binding of its ligand, CXCR4 undergoes dimerization and activates Gi G-proteins6,7. However downstream activation through CXCR4 could also occur through other G-proteins and non-G-proteins5. The down regulation of the CXCR4 receptor is initiated by phosphorylation of its cytoplasmic tail, which is followed by the binding of arrestin. The receptor is then internalized through endocytosis and degraded in the lysosome. Downregulation of CXCR4 could also occur through the stimulation of other GPCRs8.nThe distribution of CXCR4 is quite broad and involves the central nervous system (CNS)9, spleen, testes, hematopoietic and non-hematopoietic cells. ATTO dyes are characterized by strong absorption (high extinction coefficient), high fluorescence quantum yield, and high photo-stability. The ATTO-488 label is analogous to the well known dye fluorescein isothiocyanate (FITC) and can be used with filters typically used to detect FITC.

免疫原: CXCR4 (胞外)-ATTO-488抗體的免疫原肽段為(C)EGISIYTSDNYTEE。此免疫原序列來源于2-15 位氨基酸殘基，該序列來源于人類 CXCR4 (Accession編號為 P61073)。胞外，N端。

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