有機陽離子轉運蛋白1抗體（50 ul）-Anti-Organic Cation Transporter 1代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: Organic cation transporters belong to the Solute carrier family 22 (SLC22) and the MATE family. The SLC22 family contains the three subtypes of passive diffusion organic cation transporters called OCT1 (SLC22A1), OCT2 (SLC22A2) and OCT3 (SLC22A3). OCT1 is responsible for the uptake of organic cationic compounds from blood to hepatocytes.nLike most members of the SLC22 family, the organic cation and carnitine transporters have a predicted membrane topology that comprises 12 α-helical transmembrane domains (TMDs), an intracellular N-terminus, a large glycosylated extracellular loop, a large intracellular loop with phosphorylation sites and an intracellular C-terminus.nIn humans, OCT1 has a broad tissue distribution, although it is primarily expressed in hepatocytes. In rat hepatocytes, Oct1 has been located at the sinusoidal membrane4. OCT1 is also expressed in cholangiocytes5. Human OCT1 is also expressed at the apical membrane of epithelial cells in the proximal and distal tubules of the nephron.nA recent study demonstrated that primary liver cancer derived from epithelial cells, namely, hepatocellular carcinoma (HCC), cholangiocarcinoma (CGC), and hepatoblastoma, shares a decreased expression of OCT1 as a common feature7. The reduction in the expression levels of this transporter has been associated with advanced tumor stages and poorer overall patient survival rates in HCC and CGC5.

免疫原: Organic Cation Transporter 1抗體的免疫原肽段為(C)ENLGRRKSKAKENT。此免疫原序列來源于530- 543 位氨基酸殘基，該序列來源于大鼠Organic Cation Transporter 1 (Accession編號為Q63089)。胞內, C端

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