Urotensin II is a very powerful vasoconstrictive substance. The human Urotensin II receptor (UTIIR) was originally isolated as an orphan receptor (GPR14) in neural and sensory tissues.Urotensin II is expressed in various human tissues such as CNS, skeletal muscle, smooth muscle, pancreas, and heart. Binding of Urotensin II to the receptor leads to activation of phospholipase C. The resulting increase in intracellular Ca2+ may cause the contraction of vascular smooth muscle. ERK1/2 phophorylation may also be involved in mediating the biological activities of urotensin II.6 Recently, evidence has accumulated indicating that Urotensin II is also expressed in various kinds of tumor cells such as of adrenal tumors and neuroblastomas. In those cells Urotensin II was reported to stimulate cell growth.
應用類型
經驗證，該抗體可應用于IH、WB等實驗。
免疫原
Urotensin II 受體抗體的免疫原肽段為(C)RPLDTVQRSKGYRK。此免疫原序列來源于154-167 位氨基酸殘基，該序列來源于大鼠UTIIR (Accession編號為P49684)。 第二胞內環。
來源宿主
兔
反應性
反應性：大鼠
保存建議
艾美捷為您提供的Urotensin II 受體抗體(50 ul)為室溫運輸，建議您收到產品后﹣20℃保存。
