人FPR1（胞外）-ATTO-488抗體（50 ul）-Anti-Human FPR1 （extracellular)-ATTO-488代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: FPR1 was originally found in neutrophils and later found to be distributed in myeloid and non-myeloid cells as is the case for FPR2/ALX and FPR3 (FPR3 though is not expressed in neutrophils). FPR1 is also expressed in multiple organs and tissues including epithelial cells in organs with secretory functions, endocrine cells, liver hepathocytes, smooth muscle cells and endothelial cells, brain spinal cord and both motor and sensory neurons4. FPR2/ALX has a similar tissue distribution to that of FPR1.nWhile N-formyl peptides were the first peptides found to activate these receptors, the ligand diversity for FPR has proven to be quite broad and demonstrates to be both pro- and anti-inflammatory. They include peptidic ligands originating from bacterial and viral sources (including HIV), endogenous ligands such as chemokines and annexins, short peptides associated with inflammation and infection. Indeed, peptides from Herpes, Ebola and coronavirus 229E are ligands of FPR11. ATTO dyes are characterized by strong absorption (high extinction coefficient), high fluorescence quantum yield, and high photo-stability. The ATTO-488 label is analogous to the well known dye fluorescein isothiocyanate (FITC) and can be used with filters typically used to detect FITC.

免疫原: Human FPR1 (胞外)-ATTO-488抗體的免疫原肽段為(C)NFSPWTNDPKERIN。此免疫原序列來源于179-192 位氨基酸殘基，該序列來源于人類FPR1 (Accession編號為P21462)，第二胞外環。

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