- 中文名稱
游離脂肪酸受體1（胞外）抗體（50 ul）
- 英文名字
- Anti-Free Fatty Acid Receptor 1 （extracellular)
- 供應商
- Alomone
- 產品貨號
- ALO-AFR-011-50
- 產品報價
- ￥已停產
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868。
- 產品新聞
- 背景資料
- Free fatty acids (FFAs) were for long believed to influence cellular metabolism. Hoever, the discovery that FFAs actually mediate their effects through one of three G-protein coupled receptors (GPCRs) - Free Fatty Acid Receptors 1-3 (FFAR1-3), has initiated a number of studies in order to assess their implication in health and disease.nLike all other GPCRs, FFAR1-3 have seven transmembrane domains, an extracellular N-terminal tail and an intracellular C-terminus.nFFAR1 is activated by either medium or long, saturated or unsaturated fatty acids, whereas FFAR2 and FFAR3 are activated by short chain fatty acids. FFAR1 is coupled to Gq and leads to Ca2+ mobilization upon activation. FFAR2 couples to both pertussis-sensitive and insensitive G-proteins and also leads to increased intracellular Ca2+ levels. FFAR3 coupling to G-protein induces an increase in cAMP1.nDistribution studies of all three FFA Receptors indicate that FFAR1 mRNA is quite elevated in the pancreas. FFAR1 is also detected in the liver, heart, skeletal muscle, and brain; although this broad localization pattern is supported only by one study. FFAR2 is expressed in many tissues like liver and colon6. FFAR3 is expressed in many tissues but shows highest expression in adipose tissue4. Relatively high expression of the receptor could be detected in pancreas, spleen, lymph nodes and bone marrow.nAs mentioned above, the finding that FFAs’ actions are mediated by GPCRs, prompted many studies in order to elucidate their roles in healthy and disease states. Such studies stipulate that FFAR1 may be involved in obesity and type 2 diabetes since circulating free fatty acid levels in the plasma are significantly elevated. On the other hand, FFAR2 and FFAR3 could be potential targets for treating irritable bowel disease and appetite control.
- 應用類型
- 經驗證，該抗體可應用于WB
- 免疫原
- Free Fatty Acid 受體 1 (胞外)抗體的免疫原肽段為肽段：, (C)NVASFINPDLEGSWRK 對應的氨基酸殘基： 244-259 位氨基酸殘基，該序列來源于大鼠free fatty acid 受體 1 (Accession編號為Q8K3T4)
- 來源宿主
- 兔
- 反應性
- 反應性：大鼠
- 保存建議
- 艾美捷為您提供的Free Fatty Acid 受體 1 (胞外)抗體(50 ul)為室溫運輸，建議您收到產品后﹣20℃保存。
- 其他
- Alomone成立于1989年,已經成為全世界科學家信賴的最全面的離子通道研究工具供應商。產品覆蓋離子通道、G蛋白耦聯受體和神經信號研究所需的一抗、小分子、蛋白質和多肽等。所有Alomone產品均進行了生物實驗驗證，以凍干粉形式提供，可確保產品生物活性和保質期。Alomone可提供多種包裝規格，靈活方便。作為Alomone Labs在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Alomone Labs產品以及客戶訂制化服務。
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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