Frizzled-2（胞外）抗體（25 ul）-Anti-Frizzled-2 （extracellular)代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: Frizzled receptors (FZD) belong to the super family of G-protein coupled receptors (GPCR). They are classified to the frizzled subfamily for which 11 members have been identified to date; FZD1-10 and Smoothened. They were first identified in Drosophila melanogaster.nLike all GPCRs, Frizzled receptors have seven transmembrane domains, an extracellular N-terminus and an intracellular C-terminal tail. However, these receptors lack many features of the conventional class A, B or C GPCRs.nActivation of these receptors by WNT, leads to numerous complex signaling pathways which are generally termed β-catenin-dependent and β-catenin-independent. It is noteworthy to mention that the β-catenin-dependent pathway involves the interaction of FZD with LRP6 or LRP5 co-receptors.nFrizzled receptors are ubiquitously expressed and play a crucial role in embryo development. They are also significantly involved in proliferation and differentiation. Indeed, dysregulation of FZD leads to various forms of cancer1. Scientific evidence also shows their involvement in axonal remodeling and neurotransmitter release.nThey have been associated to Alzheimer’s and Parkinson’s disease, depression, anxiety, hypoxia and ischemia. It is thus not surprising that they have become pharmacological targets in a number of diseases and disorders.

免疫原: Frizzled-2 (胞外)抗體的免疫原肽段為(C)GAPPRYATLEHPFH。此免疫原序列來源于192- 205 位氨基酸殘基，該序列來源于大鼠Frizzled-2 (Accession編號為Q08464)。胞外，N端。

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