GABA（A）Alpha6受體（胞外）抗體（50 ul）-Anti-GABA （A) Alpha6 Receptor （extracellular)代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake and metabolism occur in the nervous system.nThe GABA transmitter interacts with two major types of receptors: ionotropic GABA(A) and the metabotropic GABA(B) receptors. The GABA(A) receptor belongs to the ligand gated ion channel superfamily.nThe GABA(A) R, is a heteropentamer, with all of its five subunits contributing to the pore formation. nTo date, eight subunit isoforms were cloned: α, β, γ, δ, ε, π, θ, and ρ.1 Six α subunit isoforms were described to exist in mammals (α1-α6). The native GABA(A) receptor, in most cases, consists of 2α, 2β and 1γ subunit. The α subunit is the most common subunit and is expressed ubiquitously. nIt determines the affinities for allosteric ligands shown by GABA(A)R. nA possible role for the GABA(A) receptors in alcohol action has been derived from animal studies, in vitro cell models and human research which suggested an important role for GABA(A) α6 along with β2, α1 and γ2, in alcohol related phenotypes.nIn Canavan disease (inherited leukodystrophy), low level of expression of GABA(A) α6 was reported.

免疫原: GABA (A) Alpha6 受體 (胞外)抗體的免疫原肽段為QLEDEGNFYSENVSRILDN(C)。此免疫原序列來源于20-37 位氨基酸殘基，該序列來源于大鼠GABA(A) α6 受體 (Accession編號為 P30191)。 Extracellullar, N端

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