GABA（A）Alpha4（胞外）抗體（50 ul）-Anti-GABA（A) Alpha4 （extracellular)代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake, and metabolism all occur in the nervous system.nThe GABA transmitter interacts with two major types of receptors: ionotropic GABAA receptors (GABAAR) and metabotropic receptors (GABABR). GABAARs belong to the ligand-gated ion channel superfamily. GABA inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells3. Binding of GABA to its GABAA receptor results in conformational changes that open a Cl- channel, producing an increase in membrane conductance that results in inhibition of neural activity.nGABAARs are heteropentamers, in which all five subunits contribute to the pore formation. To date, eight subunit isoforms have been cloned: α, β, γ, δ, ε, π, θ, and ρ1. Six α subunit isoforms have been found to exist in mammals (α1-α6). In most cases, native GABAA receptors consist of 2α, 2β, and 1γ subunits. The α subunit is the most common and is expressed ubiquitously. It determines the affinity of GABAARs for allosteric ligands.nEach subtype has a unique regional expression in the brain, and individual neurons often express multiple subtypes4. For example, the α4 subunit is detected in the hippocampus, cortex, olfactory bulb and in the basal forebrain

免疫原: GABA(A) Alpha4 (胞外)抗體的免疫原肽段為NSKDEKLSPENFTR(C)。此免疫原序列來源于37-50 位氨基酸殘基，該序列來源于大鼠 GABA(A) α4 ，替代 C44 with serine (Accession編號為 P28471 )。胞外，N端。

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