GABA（A）Theta受體（胞外）抗體（50 ul）-Anti-GABA（A) Theta Receptor （extracellular)代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: The A-type receptors for γ-aminobutyric acid (GABA(A)) mediate the majority of fast inhibitory transmission in the mammalian central nervous system. Many clinically important drugs including benzodiazepines, barbiturates and general anesthetics act as positive allosteric modulators of this receptor1. GABA(A) receptors are pentameric ligand-gated ion-channels, composed of subunits from many subunit classes: α1-α6, β1-β4, γ1-γ4, δ, ε , θ, π and ρ1-ρ32. The arrangement of subunits around the channel is probably γβαβα counter-clockwise when viewed from the extracellular space, ε and π subunits can replace the γ and δ subunit within the pentamer, whereas the θ subunit could replace a β subunit.nThe localized expression of this subunit is consistent with the fact that all GABA(A) receptor subunit genes have distinct expression patterns in the brain3. The θ subunit has been reported to be strongly expressed in the striatum and has been localized to the locus ceruleus.nImpairment of the γ-aminobutyric acid (GABA) signaling system is believed to partially account for behavioral and cognitive deficits associated with schizophrenia and mood disorders5. Reduction of GABA(A) mediated signal transmission has also been associated with anxiety, panic, impaired learning and memory.

免疫原: GABA(A) Theta 受體 (胞外)抗體的免疫原肽段為DYRMHEKLWVPDC。此免疫原序列來源于131-143 位氨基酸殘基，該序列來源于小鼠 GABA(A) θ 受體 (Accession編號為Q9JLF1)。胞外，N端。

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