GABA（A）Rho3受體（胞外）抗體（25 ul）-Anti-GABA（A) Rho3 Receptor （extracellular)代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: γ-Aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter. It is involved in roughly 40% of the inhibitory synapses.nGABA acts through two receptors, GABA(A) and GABA(B). To date, nineteen different GABA(A) subunits have been identified and divided in eight subunits: α (1-6), β (1-3), γ (1-3), δ, ε, ρ (1-3), θ and π. For some of the subunits, alternative splicing further increases the number of existing receptor types. They all have extracellular N- and C-termini and four transmembrane domains.nThree ρ subunits have been detected: GABA(A) ρ1, GABA(A) ρ2 and GABA(A) ρ3. Like all GABA(A) receptors the ρ subunits also assemble into a pentameric structure forming a Cl- channel. However, in contrast to all other GABA(A) subunits they mostly form homomeric entities. The GABA(A) ρ subunits display different pharmacological characteristics and were therefore once referred to GABA(C) receptors. GABA(A) and GABA(B) respectively respond to bicuculline and baclofen, whereas ρ subunits are insensitive to either drug. In addition, ρ subunits also display different electrophysiological properties, and are significantly more sensitive to GABA.nρ subunits are highly expressed in the retina and it was believed that they are only expressed in that area. They are however, also expressed in central and peripheral nervous systems, as well as in the gastrointestinal and cardiovascular systems

免疫原: GABA(A) Rho3 受體 (胞外)抗體的免疫原肽段為CLSSPKQTRIRETR。此免疫原序列來源于31-44 位氨基酸殘基，該序列來源于大鼠GABA(A) ρ3 受體 (Accession編號為P50573)。

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