GABA（B）R1（胞外）抗體（50 ul）-Anti-GABA （B) R1 （extracellular)代理/參數/廠家-一抗-艾美捷科技有限公司

PRODUCT CENTER

一抗

產品中心

當前位置：首頁 > 產品中心 > 免疫學產品 > 一抗

背景資料: GABA (gamma-aminobutyric acid) is the major inhibitory neurotransmitter in the central nervous system and plays a crucial role in the modulation of neuronal activity.nThe GABA transmitter interacts with three types of receptors: the ionotropic receptors, GABA (A)R and GABA (C)R, and the metabotropic GABA (B) receptor, [GABA (B)R].The latter belongs to the G-protein-coupled receptor superfamily and mediates slow synaptic inhibition in the brain and spinal cord.nThe functional GABA (B) receptor [GABA (B)R] is a heterodimer consisting of two subunits, the GABA (B)R1 and the GABA (B)R2. These subunits were demonstrated to have complementary roles essential for the functional receptor.5,6 The GABA (B)R1 subunit was demonstrated to be important for agonist and antagonist binding, while GABA (B)R2 was shown to be essential for trafficking and for G-protein binding.nTo date, eight alternatively spliced isoforms of GABA (B) R1 have been proposed. These are named 1a-1h, of which 1a and 1b are the most prominent. Only 1a, 1b, and 1c appear to act as functional subunits.They are widespread, being expressed in testis, stomach, spinal cord, and brain. Isoform 1b is also expressed in kidney and liver.

免疫原: GABA (B) R1 (胞外)抗體的免疫原肽段為CRGEREVVGPKVRK。此免疫原序列來源于66-79 位氨基酸殘基，該序列來源于大鼠GABA(B) R1 (Accession編號為Q9Z0U4)。胞外, N端

其他: Alomone成立于1989年,已經成為全世界科學家信賴的最全面的離子通道研究工具供應商。產品覆蓋離子通道、G蛋白耦聯受體和神經信號研究所需的一抗、小分子、蛋白質和多肽等。所有Alomone產品均進行了生物實驗驗證，以凍干粉形式提供，可確保產品生物活性和保質期。Alomone可提供多種包裝規格，靈活方便。作為Alomone Labs在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Alomone Labs產品以及客戶訂制化服務。