- 中文名稱
Kainate受體GluK4（胞外）抗體（50 ul）
- 英文名字
- Anti-Kainate Receptor GluK4 （extracellular)
- 供應商
- Alomone
- 產品貨號
- ALO-AGC-041-50
- 產品報價
- ￥已停產
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868。
- 產品新聞
- 背景資料
- Glutamate is the principal excitatory neurotransmitter in the central nervous system (CNS). Glutamate is involved in cognitive functions like learning and memory in the brain. Imbalances in glutamatergic transmission have profound physiological and behavioral consequences1. Ionotropic glutamate receptors are classified functionally and by molecular homology into three receptor classes: N-methyl-D-aspartate (NMDA), amino- 3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kainate (KA). KA receptors assemble as tetramers from five subunit types, GluK1, GluK2 GluK3, GluK4 and GluK5. The GluK1-GluK3 subunits have low glutamate affinity and are capable of forming functional homomeric channels. GluK4 and GluK5 are high-affinity kainate receptor subunits that bind glutamate but require coassembly with one or more GluK1-GluK3 subunits to form functional channels. The heteromultimeric assembly of kainate receptors like many other ion channels leads to the formation of receptors with unique pharmacological and functional properties3. Unlike the other KA receptor subunits, which are expressed throughout the CNS, GluK4 expression is limited to only a few regions of the brain, and expression is highest in the CA3 region of the hippocampus and dentate gyrus.nThe GluK4 receptor subunit gene, GRIK4, is located near the tip of the long arm of chromosome 11. Genetic variants in the GRIK4 gene have been demonstrated to associate with several psychiatric disorders. GRIK4 has been identified as a susceptibility gene in schizophrenia and bipolar disorder5. GluK4 may also play a role in excitotoxic Neurodegeneration.
- 應用類型
- 經驗證，該抗體可應用于IH、WB等實驗應用，也可用于 FC、IC、IP、LCI等實驗。
- 免疫原
- Kainate 受體 GluK4 (胞外)抗體的免疫原肽段為(C)KNRINRAPERLGK。此免疫原序列來源于49-61 位氨基酸殘基，該序列來源于大鼠GluK4 (Accession編號為Q01812)。胞外，N端。
- 來源宿主
- 兔
- 反應性
- 反應性：人、 小鼠、 大鼠
- 保存建議
- 艾美捷為您提供的Kainate 受體 GluK4 (胞外)抗體(50 ul)為室溫運輸，建議您收到產品后﹣20℃保存。
- 其他
- Alomone成立于1989年,已經成為全世界科學家信賴的最全面的離子通道研究工具供應商。產品覆蓋離子通道、G蛋白耦聯受體和神經信號研究所需的一抗、小分子、蛋白質和多肽等。所有Alomone產品均進行了生物實驗驗證，以凍干粉形式提供，可確保產品生物活性和保質期。Alomone可提供多種包裝規格，靈活方便。作為Alomone Labs在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Alomone Labs產品以及客戶訂制化服務。
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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