Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes nerve growth factor (NGF) neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5).The functional importance of the prodomain of BDNF was recently demonstrated in a study showing that a polymorphism that replaces valine for methionine at position 66 of the pro domain, is associated with memory defects and abnormal hippocampal function in humans. Another recent study showed that the regulated extracellular cleavage of proBDNF to mature BDNF by plasmin is necessary for establishing late-phase long-term potentiation (L-LTP) a process that involves long-lasting changes in the structure and function of hippocampal synapses. Finally, proBDNF was shown to be decreased in the brains of patients suffering from Alzheimer’s disease.
應用類型
經驗證，該抗體可應用于IH、WB等實驗應用，也可用于 CBE、IC、IFC、IP等實驗。
免疫原
proBDNF抗體的免疫原肽段為(C)DEDQKVRPNEENNKDAD。此免疫原序列來源于72-88位氨基酸殘基，該序列來源于人類BDNF (precursor) (Accession編號為P23560 )。 Pro-結構域 of the BDNF蛋白。
